Abstract: Butanone 1,2-pmpanediol ketal was synthesized from butanone and 1,2-propanediol in the presence of H₃PW₆Mo₆O₄₀/MCM-48. The effects of the molar ratio of hutanone to 1,2-propanediol, catalyst dosage and reaction time on the yield of hutanone 1, 2-propanediol ketal were investigated. The catalytic activity of H₃PW₆Mo₆O₄₀/MCM-48 was discussed by the orthogonal experiment. The results show that H₃PW₆Mo₆O₄₀/MCM-48 is an excellent catalyst for synthesizing butanone 1,2-propanediol ketal and the yield can be up to reach 81.0% under the condition that the molar ratio of butanone to 1,2-propanediol is 1:1.4, the mass percent of catalyst is 0.2% of feed stocks, and the reaction time is 1.0h.