Abstract: Shuichang open-pit iron mine in China was taken as the engineering project of the study. Based on systematical investigation and study of engineering-geological conditions, rock mass structures, hydro-geological and permeability field conditions, in situ stress measurement, physical and mechanical property tests of rock mass, the stability analysis and design optimization of the slope for Shuichang open-pit mine were completed. Through the study, the overall slope angle for every sub-zones is increased 1-6°.