Abstract: The compound artificial synovia was prepared according to the table of orthogonal test design, which three factors-Hyaluronic Acid, γ-globulin and Lα-DPPC and five levels were considered. A pendulum type friction test made by author was used to determine the friction coefficient of two kinds of tribology slide pairs-PVA-H/PVA-H and PVA-H/316L S S lubricated by the compound artificial synovia, the appropriate properties of three factors in the compound artificial synovia selected were ascertained finally.