Abstract: An image compression method with Visual Entropy-Based segmentation is presented. Firstly the induction of the characteristics of Human Vision System(HVS) and the principles for Visual Entropy-based segmentation is made. Then the mathematic definition for quantification of image character and the algorithm for Visual Entropy-Based segmentation are fully described. The experimental results have shown that image compression with Visual Entropy-Based segmentation can not only gets a rather low bit rate but also gives satisfactory subjective perceptual quality. This method has well emulated the properties of HVS.